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The function of SIK1 in tumorigenesis. SIK1 is often a tumor suppressor gene, which performs a significant regulatory position in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and affects most cancers cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may also endor